Linkage-specific deubiquitylation by OTUD5 defines an embryonic pathway intolerant to genomic variation

Beck DB*, Basar MA*, Asmar AJ, Thompson JJ, Oda H, Uehara DT, Saida K, Pajusalu S, Talvik I, D'Souza P, Bodurtha J, Mu W, Barañano KW, Miyake N, Wang R, Kempers M, Tamada T, Nishimura Y, Okada S, Kosho T, Dale R, Mitra A, Macnamara E; Undiagnosed Diseases Network, Matsumoto N, Inazawa J, Walkiewicz M, Õunap K, Tifft CJ, Aksentijevich I, Kastner DL, Rocha PP, Werner A. Linkage-specific deubiquitylation by OTUD5 defines an embryonic pathway intolerant to genomic variation. Sci Adv . 2021 Jan 20;7(4):eabe2116. doi: 10.1126/sciadv.abe2116. PMID: 33523931; PMCID: PMC7817106. Online Article