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David B. Beck
David B. Beck
Principal Investigator

David.Beck@nyulangone.org  

David is the principal investigator of the lab and runs the Inflammatory Disease Genetics Clinic in the Department of Medicine. He received his B.A. from Brown University in the Departments of History and Biology. He earned his M.D./Ph.D. from New York University in the laboratory of Dr. Danny Reinberg. He continued with clinical training in the clinician scientist pathway in Internal Medicine at Columbia University and then went on to perform Clinical Genetics training at the National Institutes of Health and Johns Hopkins combined program. David performed his postdoctoral research with Dr. Dan Kastner at the National Institutes of Health.


Sam Magaziner
Sam Magaziner
Graduate Student

Samuel.Magaziner@nyulangone.org  

Sam is an MD/PhD candidate within the New York University Grossman School of Medicine’s Medical Scientist Training Program (MSTP). His work revolves around elucidating the mechanism of disease in patients with VEXAS and  characterizing the role of the master regulator of the Ubiquitin-Proteasome System (UPS), UBA1, in physiological and disease states.  He received his B.A. in Biochemistry from Columbia University.  He earned his MPhil in Biological Sciences from the University of Cambridge in the laboratory of Prof. George Salmond.  Prior to joining the NYU GSoM MSTP, Sam was an IRTA fellow at the National Institutes of Health where he worked in the group of Dr. Heather Hickman examining mechanisms of adaptive immunity in the setting of viral infection.  In his free time Sam enjoys entrepreneurship, reading and writing science fiction, and caring for his pet chameleon Clive.


Brecca Miller
Brecca Miller
Graduate Student

Brecca.Miller@nyulangone.or  

Brecca is a  PhD candidate in the Computational Biomedicine program at NYU with Dr. Kelly Ruggles as her co-mentor. Brecca’s current work involves characterizing genetic, transcriptomic, and proteomic markers of autoinflammatory diseases. Brecca graduated from University of Florida with a major in Biomedical Engineering and worked on studying allele specific expression and computational tool development in the lab of Dr. Lauren McIntyre. She enjoys  hiking, rock climbing, and listening to music.


Ayana Sawai-Frantz
Ayana Sawai-Frantz
Postdoctoral Fellow

Ayana.Sawai@nyulangone.org  

Ayana is a post-doctoral fellow, currently establishing and characterizing VEXAS mouse models to investigate the effects of UBA1 in hematopoietic development and the molecular mechanisms of inflammation. She received her B.S. from Bates College, ME, and her PhD from NYU Grossman School of Medicine, Vilcek Institute. Prior to her graduate school, she contributed to the development of therapy for B-Raf mutated melanoma cancer at MSKCC in Dr. Neal Rosen’s group. For her thesis work in Dr. Jeremy Dasen’s lab, she dissected the mechanisms of epigenetic regulation in motor neuron cell fate decision. She is excited to expand her horizons in immunology with her experience in Molecular Pharmacology and Developmental Neuroscience. Outside of science, she enjoys world history, cooking and biking.


Maria Sirenko
Maria Sirenko
Postdoctoral Fellow

Maria.Sirenko@nyulangone.org  

Maria is a Postdoctoral Fellow in the lab co-mentored by Dr. Iannis Aifantis. She is working on identifying novel drivers of overlapping inflammatory disease and myeloid malignancy. She received her B.S. in Biomedical Engineering from Cornell University and her Ph.D. at Memorial Sloan Kettering Cancer Center in the lab of Dr. Elli Papaemmanuil. During her Ph.D., she established integrative single cell frameworks to study genetic and cellular heterogeneity in IDH-mutated acute myeloid leukemia and defined how cooperative mutations shape treatment response. She also studied the overlap of VEXAS and myelodysplastic syndromes (MDS) and defined the prevalence, co-mutation patterns, and clinical associations of UBA1 mutations in a large, international cohort of MDS patients.


Niharika Srivastava
Niharika Srivastava
Postdoctoral Fellow

Niharika.Srivastava@nyulangone.org  

Niharika is a post-doctoral fellow in the laboratory and currently studying the mechanism underlying rare genetic diseases. She received her B.Sc and M.Sc. degree from the Banasthali University, Rajasthan, India.  Her Ph.D. involved the immune signaling in the Vitiligo disease which she has done with Dr. Davinder Parsad (PGIMER, Chandigarh, India) and Dr. Sarika Gupta (Banasthali University, Rajasthan, India).


Flore Castellan
Flore Castellan
Postdoctoral Fellow

Flore.Castellan@nyulangone.org  

Flore is a post-doctoral fellow, working on bioinformatic approaches to characterize somatic mutations. She received her M.Sc. degree from the multidisciplinary engineering school ESPCI in Paris and her Ph.D. from the embryology lab at the University of Tokyo. Her thesis research revealed the immune influence of maternal cells on the development of the neonatal immune system in mice, combining wet and dry lab. She’s also a jack of all trades in her hobbies, enjoying crafts, games as well as performances and outdoor activities.


Mei-Kay Wong
Mei-Kay Wong
Genetic Counselor

Margaret.Wong2@nyulangone.org  

Mei-Kay is a board-certified genetic counselor and public health professional interested in patient advocacy and health equity. She received her B.S. in Biology and Psychology at the University of Notre Dame before earning her M.S.in Genetic Counseling as well as her M.P.H. in Public Health Genetics at the University of Pittsburgh, where she was awarded a fellowship from the New York Mid-Atlantic Consortium (NYMAC) for Genetic and Newborn Screening Services. When not coordinating clinical care or research studies delving into the genetic mechanisms of known or (as of now) undiagnosed disorders of inflammation, she enjoys playing volleyball, finding her next favorite song, and snacking.


Daniela Ospina Cardona
Daniela Ospina Cardona
Genetic Counselor

Daniela.OspinaCardona@nyulangone.org  

Daniela is currently characterizing novel mutations causing autoinflammatory diseases. She received her B.S. from the University of Maryland, Baltimore county, and was previously an IRTA fellow at the National Institutes of Health. She is currently a genetic counseling student at University of Maryland continuing to work with the Beck lab.


Maryel Likhite
Maryel Likhite
Research Associate

Mary.Likhite@nyulangone.org  

Mary is a research associate in the laboratory. She is currently using exome and genome sequencing data to try to identify new genetic drivers of disease. Mary graduated from Saint Michael’s College with a BA in general biology and a minor in chemistry. She worked at Dartmouth-Hitchcock Medical Center as a lab assistant in the Clinical Genomics and Advanced Technologies Lab as well as the Microbiology Lab. Mary will receive a master’s degree in applied genomics from the University of Connecticut in December 2022,


Sachiko Keane
Sachiko Keane
Research Associate

Sachiko.Keane@nyulangone.org  

Sachiko has an undergraduate degree in Neuroscience and a concentration in Statistics from Columbia University. She is currently a Research Associate in the Beck Lab establishing the autoimmune inflammatory disease VEXAS in mouse models. Sachiko is also a competitive archer and enjoy shooting on weekends.


Defne Ercelen
Defne Ercelen
Research Associate

Defne.Ercelen@nyulangone.org  

Defne is a research associate working on the genetic architecture of autoimmune diseases. She is interested in using large scale data to identify associations between clinical phenotypes and genomic traits. She is also part of the IBD research team at NYU Langone under Dr. Jordan Axelrad. She received a B.S. in computational and systems biology with a concentration in bioinformatics from UCLA, where she completed her thesis work in the diversity of genomic features detectable by exome sequecning in Dr. Noah Zaitlen’s lab. Other than genomics, she completed a minor in art history in UCLA and a certificate program in Art & Business at Sotheby’s Institute of Art.


Deborah Hernandez
Deborah Hernandez
Lab Manager

Deborah.Hernandez@nyulangone.org  

Deborah Hernandez is the lab manager for the Beck Lab. She has extensive experience as a technician and lab manager with Dr. Danny Reinberg first at UMDNJ and then more recently at NYU.


Name Role in the lab Where are they now?
Bibi Subhan Graduate Rotation Student Graduate Student in Scwab lab
Dinesh Babu Uthaya Kumar Postdoctoral fellow Postdoctoral Fellow- Yale University
Anna Cantor Genetic Counselor Program Director for Genetics Education
Meghan Anderson Clinical Fellow Assistant Professor, University of Pennsylvania
Athena Lam Undergraduate Student