New Publication!

We are excited to share that our collaborative work with the Werner lab at NIH was published in the EMBO Journal  ( In this work, we characterize disease causing mutation in UBA1  in vitro and in vivo to define the mechanisms underlying VEXAS syndrome, XL-SMA, and Lung Cancer in Never Smokers (LCINS). We define an E2 bottleneck present in VEXAS syndrome and shared mechanisms across disease subtypes. Congratulations to all of the team!